Chapter1 Introduction
1.1 Case Analysis
1.2 Clinical Epidemiology
1.3 Methodology of Clinical Epidemiology
1.4 Roles and Significance of Clinical Epidemiology
1.5 Organization of the Book
Chapter2 Evaluation of Diagnostic Tests
2.1 Clinical Scenario
2.2 Design of a Diagnostic Test
2.3 Validity of Diagnostic Tests
2.4 Important Issues in Study Design of Diagnostic Tests
2.5 Possible Bias in Diagnostic Tests
2.6 Standards for the Reporting of Diagnostic Accuracy Studies
2.7 Case Study on Evaluation of a Diagnostic Test
Chapter 3 Evaluation of Etiological Studies
3.1 Case Analysis
3.2 Concept of Etiology in Epidemiology
3.3 Causal Inference
3.4 Major Epidemiological Research Methods in Etiological Evaluation
Chapter 4 Clinical Trials
4.1 Case Study
4.2 Introduction to Randomized Controlled Trials
4.3 Essential Elements of a RTC Study
4.4 Limitations of RCTs
4.5 Reporting of Trials and CONSORT
Chapter 5 Prognosis
5.1 Clinical Scenario
5.2 Clinical Questions
5.3 Prognosis
5.4 Some Concepts
5.5 Research Methods for Prognostic Studies
5.6 Describing Prognosis as a Rate
5.7 Survival Analysis
5.8 Bias in Prognostic Studies and Controlling Methods
5.9 Guidelines for Assessing Evidence about Prognostic Studies
Chapter 6 Prevention
6.1 Clinical Scenario
6.2 What is Prevention? Why Prevent?
6.3 Levels of Prevention
6.4 Screening Test
Chapter 7 Clinical Research, Clinical Guidelines and Clinical Practice
7. 1 Clinical Scenario
7.2 Randomized Clinical Trials
7.3 Diagnostic Tests
7.4 Research about Prognosis
7.5 Systematic Review
7.6 Clinical Guidelines
7.7 Applying the Evidence to Individual Patients
7.8 Resolution to the Clinical Scenario
Chapter 8 Methodological Tools in Clinical Epidemiology
8. 1 Clinical Scenario
8.2 Sample Size Required for Study
8.3 Resources for Evidence-based Medicine
8.4 Other BMI Resources
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