1 INTRODUCTION
What is endocrinology?
What do hormones do?
Types of hormone: their synthesis and secretion
The tra port and metabolism of hormones
Important concepts in endocrine regulation
Endocrine disorde
Endocrine investigatio : general principles
2 RECEPTORS AND HORMONE ACTION
Introduction
General characteristics of recepto
Types of hormone recepto
Cell-membrane recepto
Hormonal regulation of tra cription
Intracellular recepto
Disorde of receptor function
3 THE HYPOTHALAMUS AND PITUITARY PART I: THE HYPOTHALAMUS AND
POSTERIOR PITUITARY
Introduction
Where can I find the hypothalamus and pituitary?
Connection between the hypothalamus and pituitary
Development of the hypothalamus and pituitary
The hormones of the hypothalamus
The hormones of the posterior pituitary
Release of posterior pituitary hormones is part of a
neuroendocrine reflex: oxytocin secretion and actio
Regulation of vasopressin secretion
Actio of arginine vasopressin
Disorde of vasopressin secretion and action
Thi t
Other hypothalamic hormones
4 THE HYPOTHALAMUS AND PITUITARY PART II: THE ANTERIOR
PITUITARY
Introduction
Structure of the anterior pituitary
The hormones of the anterior pituitary
Regulation of hormone secretion in the anterior
pituitary
Growth hormone and prolactin in blood
Actio of the anterior pituitary hormones growth:
hormone and prolactin
Disorde of anterior pituitary function:
over-secretion
Disorde of under-secretion of anterior pituitary
hormones
Tests for hypopituitarism
I ufficient growth hormone secretion
5 THE ADRENAL GLANDS PART I: THE ADRENAL MEDULLA
Introduction
Where to find the adrenal glands
Blood supply
Nerve supply
Embryology of the adrenal gland
The adrenal medulla
Disorde of the adrenal medulla:
phaeochromocytorna
Familial phaeochromocytoma
Pharmacological uses of hormones of the adrenal
medulla
6 THE ADRENAL GLANDS PART II: THE ADRENAL CORTEX
Introduction
Structure of the adrenal cortex
Hormones produced by the adrenal
cortex
Regulation of steroid production
Tra port of steroid hormones in blood
Disorde of adrenal steroids
Pharmacological use of glucocorticoids
7 THE THYROID GLAND
Introduction
Thyroid anatomy
What is a goitre?
Blood supply
Structure of the thyroid
Synthesis of thyroid hormones
Iodine
Thyroxine and T3: the thyroid hormones in blood
Control of thyroid function
Cellular action of thyroid hormones
Effects of thyroid hormones
Disorde of thyroid hormone secretion
Causes of thyroid hyposecretion
Effects of thyroid hormone i ufficiency: myxoedema
8 HORMONAL CONTROL OF REPRODUCTION PART I: MALE REPRODUCTIVE
SYSTEM
Introduction
Where are the testes?
What are the testes?
Testicular blood and nerve supply
Spermatogenesis
Androgen production
Hormonal control of testicular function
Tra port of testosterone in blood
Actio of testosterone
Hormone-dependent cancer in men
Disorde of male reproduction
Therapeutic uses of androge
Abuse of anabolic androgenic steroids
Declining sperm counts
9 HORMONAL CONTROL OF REPRODUCTION PART II: FEMALE
REPRODUCTIVE SYSTEM
Introduction
Structure of the ovary
Ovarian hormones
Tra port and metabolism of oestrogen and
progesterone
Oestroge
Androgen secretion by,the ovaries
Hormonal regulation of ovarian function
Hormone-dependent cancer in women
The me trual cycle
Disorde of the me trual cycle
The endocrinology of pregnancy
10 HORMONAL CONTROL OF REPRODUCTION PART III: DEVELOPMENT AND
FERTILITY
Introduction
Gender determination and differentiation
Hormonal control of sexual differentiation
Abnormalities of sexual differentiation
Hormones during development: puberty and menarche
Disorde of puberty
Menopause and the climacteric
Premature ovarian failure
Symptoms of the menopause
Hormone replacement therapy
Alternative therapies
Hormonal control of fertility: contraception
Hormonal control of fertility: assisted conception
11 INSULIN AND THE REGULATION OF PLASMA GLUCOSE
Introduction
Glucose in urine
I ulin and the respo e to high blood glucose
levels
Disorde of blood glucose regulation: diabetes
mellitus
Gestational diabetes
The metabolic syndrome--a growing problem?
12 HORMONAL REGULATION OF PLASMA CALCIUM AND CALCIUM
METABOLISM
Introduction
Serum calcium
The structure, functio and endocrinology of bone
Hormones involved in the regulation of serum
calcium
Parathyroid hormone
Calcitriol: source and activation of vitamin D
Effects of other hormones on plasma calcium
Disorde of hypercalcaemia
Disorde of hypocalcaemia
Diseases of bone
A brief mention of calcitonin
Regulation of serum phosphate
13 MISCELLANEOUS HORMONES
Erythropoietin
Immune-endocrine interactio : cytokines and
eicosanoids
Age-related changes in hormone secretion
Melatonin
Gut hormones
The hormonal control of appetite: fat is an endocrine
tissue
Multiple organ disorde in endocrinology
Regulation of blood pressure and volume
The next 100 yea of endocrinology
Glossary
Index
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