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正版原版，原汁原味，留学生与双语教学用。
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| 內容簡介： |
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医学免疫学是一门独立的学科，是研究免疫系统的组织结构和功能的科学。它从不同的角度和水平来揭示免疫系统识别并消除抗原性异物的应答过程和规律，并应用这些规律来阐明免疫相关疾病发生发展的机制，达到防治相关疾病的目的。医学免疫学进展迅速，知识量大，本教材基于*基本的理论和知识，介绍了抗原、免疫器官和免疫细胞、免疫分子（抗体、补体、细胞因子、黏附分子和 MHC等）、免疫应答、免疫预防、免疫治疗、免疫诊断、免疫耐受、免疫相关疾病以及感染免疫等。本教材适用于医学专业外国留学生的医学免疫学英文教学和本科双语教学。
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| 關於作者： |
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姚智教授现任天津医科大学基础医学院免疫学系主任、天津医科大学病原生物与免疫学学科学术带头人、天津医科大学党委书记等职务。任第十七届世界支原体联盟常务理事，中华微生物学及免疫学会主任委员，中国免疫学会理事，中国医药生物技术协会临床应用委员会常务理事，中国细胞生物学与分子生物学学会临床分会常务理事，中华医学会天津分会检验学会主任委员等学术职务。任中国检验医学杂志英文版主编，中国免疫学杂志编委，中国肿瘤临床（英文版）编委，中草药编委等植物。曾获天津市教书育人十大标兵、天津市卫生系统科技先进个人；他领导的课题组获天津市卫生系统科技先进集体、天津市十五立功先进集体；天津市五一立功先进集体，他本人荣获天津市八五九五十五立功奖章、天津市劳动模范、天津市科技明星、天津市第四届青年科技奖；为国务院特殊津贴专家；天津市131工程人才培养第一层次人选；卫生部有突出贡献中青年专家；天津市授衔专家；2006年入选新世纪百千万人才工程*人选。
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| 目錄：
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Chapter 1
Introduction......................................... 1
A BRIEF OVERVIEW OF
IMMUNOLOGY................. 1
HIST ORY OF
IMMUNOLOGY................................... 10
STUDY QUESTIONS....................................................
13
Suggested readingS
.......................................... 13
Chapter 2
Antigen.................................................... 14
DEFINITION.................................................................
14
Epitopes......................................................................
14
Classification of Antigens BASED ON
IMMUNE
RESPONSE............................................. 15
DETERMINANTS OF IMMUNOGENICITY............
15
ANTIGEN
RECEPTORS.............................................. 16
ANTIGENIC
SPECIFICITY......................................... 17
STUDY QUESTIONS
................................................... 18
Suggested
readingS........................................... 18
Chapter 3 Antigen Recognition Molecules
.......................................................................
19
ANTIBODIESIMMUNOGLOBULINS...................
20
Major Histocompatibility Complex .........
25
STUDY QUESTIONS....................................................
28
Suggested
ReadingS........................................... 28
Chapter 4 The Complement System............
29
Complement
Activation................................. 29
Regulation of the Complement
System .................................................................
31
Biological Consequences of
Complement
Activation.............................. 32
Defects in the Complement System...........
34
STUDY QUESTIONS
................................................... 34
Suggested
readingS........................................... 35
Chapter 5 Organs and Tissues of the
Immune
System................................. 36
LYMPHOID
ORGANS................................................. 36
Contents
STUDY QUESTIONS....................................................
39
Suggested
ReadingS........................................... 39
Chapter 6 Immune
Cells...................................... 41
Lymphocytes...........................................................
41
Phagocytic
Cells................................................. 47
Dendritic Cells
.................................................... 48
STUDY
QUESTIONS.................................................... 48
Suggested ReadingS...........................................
48
Chapter 7 Immune
Response............................ 49
AN TIGEN PROCESSING AND
PRESENTATION...................................................
49
AC TIVATION OF HELPER T
LYMPHOCYTES.......... 51
HU MORAL IMMUNE RESPONSE
HUMORAL IMMUNITY....................................
55
PRIMARY AND SECONDARY RESPONSE ...........
58
FA CTORS INFLUENCING ANTIBODY
PRODUCTION........................................................
59
CE LL-MEDIATED IMMUNE RESPONSE
CELL-MEDIATED IMMUNITY..........................
60
CYTOKINES..................................................................
64
THEORIES OF IMMUNE
RESPONSE....................... 71
STUDY
QUESTIONS.................................................... 73
SUGGESTED READINGS...........................................
75
Chapter 8 Immunological
Tolerance........... 76
CE NTRAL T CELL TOLERANCE TO
SELFANTIGENS...............................................................
76
PE RIPHERAL T CELL TOLERANCE TO
SELFANTIGENS...............................................................
77
B C ELL TOLERANCE TO
SELF-ANTIGENS........... 78
AR TIFICIALLY INDUCED TOLERANCE IN
VIVO.........................................................................
79
STUDY QUESTIONS....................................................
80
SUGGESTED
READINGS........................................... 80
Contents
目
录
XIV 医学免疫学Meeddiiccaall
IImmuunnoollooggyy
Chapter 9
Hypersensitivity................................ 81
DEFINITION.................................................................
81
GELL AND COOMBS
CLASSIFICATION................ 81
IMMEDIATE TYPE I
HYPERSENSITIVITY.............. 81
TY PEⅡ HYPERSENSITIVITY
REACTION
ANTIBODY-DEPENDENT CYTOTOXICITY........
89
TY PEⅢ HYPERSENSITIVITY REACTION
IMMUNE
COMPLEX-MEDIATED.................... 93
TY PE Ⅳ CELL-MEDIATED
DELAYED
HYPERSENSITIVITY..............................................
96
STUDY
QUESTIONS.................................................. 101
SUGGESTED READINGS.........................................
101
Chapter 10
Autoimmunity................................ 102
PR OBABLE MECHANISMS OF
AUTOIMMUNITY................................................
102
AUTOIMMUNE
DISEASES...................................... 107
STUDY QUESTIONS..................................................
109
Suggested
readings......................................... 110
Chapter 11 Immunodeficiency Disorders......
111
PRIMARY
IMMUNoDeFICIENCIES...................... 111
SE CONDARY ACQUIRED IMMUNodEFICIENCIES
..................................................................................
117
STUDY
QUESTIONS.................................................. 125
SUGGESTED
READINGs......................................... 125
Chapter 12 Tumor Immunology.........................
126
CANCER：
ORIGIN..................................................... 126
TUMOR
ANTIGENS.................................................. 129
Cancer
Immunotherapy................................ 134
STUDY QUESTIONS..................................................
136
SUGGESTED
READINGs......................................... 137
Chapter 13 Transplantation Immunology......
138
Graft
Rejection................................................... 138
FACTORS FAVORINGALLOGRAFT SURVIVAL......
140
Mechanism Involved in Graft Rejection
................................................................................
142
Tempo of
Rejection............................................ 145
STUDY
QUESTIONS.................................................. 147
SUGGESTED
READINGS......................................... 147
Chapter 14 Immunological
Techniques.......... 149
ST AGES OF ANTIGEN-ANTIBODY
INTERACTIONS....................................................
149
ME ASUREMENT OF ANTIGEN AND ANTIBODY
................................................................................
149
PrecipitationReactions.................................
149
Agglutination
Reaction............................. 154
MO NOCLONAL ANTIBODIES AND
HYBRIDOMA
TECHNIQUE............................. 167
STUDY
QUESTIONS.................................................. 170
SUGGESTED
READINGs......................................... 171
Chapter 15 Immunoprophylaxis &
Immunotherapy...............................
172
IMMUNOPROPHYLAXIS........................................
172
IMMUNOTHERAPY..................................................
179
STUDY
QUESTIONS.................................................. 183
SUGGESTED
READINGs......................................... 183
Chapter 16 Immunity in Viral, Bacterial,
Fungal, and Parasitic
Infections.............................................
184
IMMU NITY IN
VIRALINFECTIONS...................... 184
IMMU NITY IN BACTERIAL
INFECTIONS........... 188
IMMU NITY IN FUNGAL
INFECTIONS................ 197
IMMU NITY IN PARASITIC
INFECTIONS............ 198
STUDY
QUESTIONS.................................................. 204
SUGGESTED
READINGs......................................... 204
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序言
Immunology is the study focusing on the organizational structures and functions ofimmune system. It demonstrates remarkable features of high-speed development andintersections with multiple disciplines, and gradually formed frontier branches such asmodern cellular immunology and immunogenetics. Meanwhile, immunology is an advanceddiscipline which is closely related to clinical applications. Therefore, immunology plays a keyrole in medical science, and thus become an important compulsory course for the students ofmedicine or biology.The contents of this textbook covers the knowledge from the basis of immunology toclinical applications, including overview of immunology, the antigens, components inimmune system immune organs, immune cells, immune molecules, etc. and immuneresponses. It also involves the applications of immunology immunological techniques,immunoprophylaxis and immunotherapy, etc., immune-related diseases and immunity ininfectious diseases. This edition of Medical Immunology is intended as a comprehensive,concise and valuable textbook for the foreign medical students studying in China andalso suitable for 5-year program Chinese medical students to learn the basic knowledge ofimmunology and to build up solid foundations for subsequent clinical courses of study andfuture academic studies.This textbook was edited and adapted on the basis of Textbook of Immunology [Sunil KumarMohanty, et al. Jaypee Brothers Medical Publishers P Ltd.2nd edition, 2014]. Sixteenprofessors from different universities who have been experienced in teaching immunologyfor foreign medical students joined the team for the work of this textbook. They also addedaccurate and up-to-date knowledge into each chapter according to the development ofimmunology, e.g., Chapter 16 is a completely new part in which the author explained themechanisms of immunity in viral, bacterial, fungal and parasitic infections, considering theactual health conditions in some countries where the foreign medical students come from.There might be some mistakes or omissions in this textbook since immunology is developingrapidly, we sincerely hope the readers give valuable opinions and comments through email sothat we can make corrections in the next edition.YAO ZhiDepartment of ImmunologyTianjin Medical UniversityTianjin 300070, P.R.Chinayaozhi@tmu.edu.cnJanuary 11, 2017
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